Palatability and animal models of schizophrenia
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منابع مشابه
Stereological analysis of cornu ammonis in prenatally stressed rats: a heuristic neurodevelopmental model of schizophrenia
Objective(s):The hippocampus has been implicated in pathophysiology of schizophrenia. Prenatal stress is a contributing risk factor for a wide variety of neuropsychiatric diseases including schizophrenia. This study examined long-term effects of prenatal restraint stress on the stereological parameters in the Cornu Ammonis (CA) of adult male rats as an animal model of schizophrenia. Materials ...
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Animal models of schizophrenia are important for research aimed at developing improved pharmacotherapies. In particular, the cognitive deficits of schizophrenia remain largely refractory to current medications and there is a need for improved medications. We discuss the pathophysiology of schizophrenia and in particular the possible mechanisms underlying the cognitive deficits. We review the cu...
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Schizophrenia is a severe mental disorder in which there is impaired judgement and loss of contact with reality. The lifetime prevalence of schizophrenia is approximately 1% worldwide. To understand the mechanisms and investigate the treatments of schizophrenia, the studies in animal are necessary. Several schizophrenic animal models have been produced. Some animal models have been reported irr...
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Animal models are very valuable for biomedical research. They enable to disclose pathological processes of the diseases and their treatment possibilities. Development of appropriate animal models of complex neuropsychiatric disorders, such as schizophrenia, is challenging since many clinical symptoms are difficult to replicate and assess in animals. There is strong evidence that disturbed brain...
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Schizophrenia is a multifactorial psychiatric disorder in which both genetic and environmental factors play a role. Genetic [e.g., Disrupted-in-schizophrenia 1 (DISC1), Neuregulin-1 (NRG1)] and environmental factors (e.g., maternal viral infection, obstetric complications, social stress) may act during the developmental period to increase the incidence of schizophrenia. In animal models, intera...
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تاریخ انتشار 2013